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Description : Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin.It inhibits both circulating and clot-bound thrombin.It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.
Additional Information : Bivalirudin is intended for IV use only and is supplied as a sterile, lyophilized product in single-use, glass vials. After reconstitution, each vial delivers 250 mg of bivalirudin.
Side Effects :
Very common - More than 1 in 10 people who have Bivalirudin
Minor bleeding from various sites of the body
Common - More than 1 in 100 people who have Bivalirudin
Abnormal laboratory test results
Injection site problems such as bleeding, pain, discomfort or collection of blood under the skin
Major bleeding from various sites of the body – certain types of bleeding may be fatal. Seek medical advice if you develop any Unusual bleeding
Thrombosis – this may be fatal
Uncommon - More than 1 in 1000 people who have Bivalirudin
Blood and bone marrow problems
Blood in the urine
Collection of blood under the skin
Hypersensitivity reactions such as tightness of chest, wheezing, anaphylaxis or anaphylactic shock. Anaphylaxis or anaphylactic Shock may be fatal
Lowered blood pressure
Rare - More than 1 in 10,000 people who have Bivalirudin
Irregular heart rate
Other heart problems or a heart attack
Skin rash or rashes
Very rare - Fewer than 1 in 10,000 people who have Bivalirudin compartment syndrome